Company Filing History:
2 out of 28 
1 out of 1,217 
1 out of 2,202 
Years Active: 1976-1983
Title: James A. Ellard: Innovator in Pharmaceutical Chemistry
Introduction
James A. Ellard is a notable inventor based in Dayton, OH (US), recognized for his contributions to pharmaceutical chemistry. He holds a total of 5 patents, showcasing his innovative approach to drug synthesis and production.
Latest Patents
Among his latest patents, Ellard has developed methods for the separation of triphenylphosphine oxide from methotrexate ester. He also made significant improvements in the production of methotrexate, as detailed in his U.S. Patent No. 4,080,325. His research indicates that magnesium oxide facilitates the coupling reaction by acting as an acid acceptor, with a preference for a dense grade of magnesium oxide in molar proportions of 2 to 4 moles per mole of 2,4-diamino-6-hydroxymethylpteridine. Furthermore, he has devised a method for removing triphenylphosphine oxide from the reaction stream using toluene or BTX-type solvents.
Career Highlights
Ellard has had a distinguished career, working with prominent organizations such as Monsanto Research Corporation and the United States of America, as represented by the Department of Health. His work has significantly impacted the field of pharmaceutical development, particularly in the synthesis of methotrexate.
Collaborations
Throughout his career, Ellard has collaborated with esteemed colleagues, including John L. Schaar and John M. Butler. These partnerships have contributed to the advancement of his research and innovations.
Conclusion
James A. Ellard's contributions to pharmaceutical chemistry through his patents and collaborations highlight his role as a significant innovator in the field. His work continues to influence drug synthesis and production methodologies.