Jacqueline Callihan Linnes

Title: Innovations of Jacqueline Callihan Linnes: Pioneering Paper-Based Fluidic Systems

Introduction

Jacqueline Callihan Linnes is an esteemed inventor based in West Lafayette, Indiana, recognized for her groundbreaking contributions to the field of paper-based microfluidic systems. With a notable track record of 14 patents, Linnes focuses on developing innovative solutions that enhance the efficiency and functionality of diagnostic devices.

Latest Patents

One of her most recent inventions is the "Temperature Controlled Valves for Paper-Based Microfluidic Systems." This invention features a low-cost, thermally reversible valve intended for paper-fluidic diagnostic devices. The device utilizes a tunable valve mechanism created through wax-ink printing and localized heating via thin-film resistors, enabling the controlled release of liquids through cellulose or nitrocellulose membranes. The wax-ink valve can effectively obstruct fluid flow for a sustained duration and is thermally actuated to dispense precise liquid quantities. This integrated device necessitates minimal user involvement and can be manufactured easily, adaptable to various fluid delivery and incubation requirements.

Another significant patent is for "Fluidic Control Elements for Signal Readout Enhancement in Two-Dimensional Paper Networks (2DPN)." This invention offers an enhanced approach to paper-based analytical devices and methods for chromatographic chemical or immunoassays. It introduces two additional components, a time-delay pad and a mixer, to the conventional 2D paper network device, significantly reducing smears while improving the sharpness and intensity of test readouts for multi-step assays.

Career Highlights

Linnes has made significant strides in her career by working with prominent organizations such as the Purdue Research Foundation and Potavida, Inc. Her efforts in these institutions have advanced the field of microfluidic technology and broadened the applications of paper-based diagnostic devices.

Collaborations

Throughout her career, Linnes has collaborated with noteworthy individuals, including Megan Zaiyi Chiu and Rui Shen. These partnerships have contributed to the innovative development of her patented technologies and underscored the importance of teamwork in advancing scientific research.

Conclusion

Jacqueline Callihan Linnes stands out as a leading inventor in the realm of paper-based diagnostics, with a strong foundation built on her numerous patents and collaborative efforts. Her innovations not only simplify the process of diagnostics but also offer practical solutions that bridge technology and user needs. As she continues to push the boundaries of her field, her work remains influential both in academic and commercial landscapes.