Purdue Research Foundation

Massachusetts Institute of Technology

Boston University

Potavida, Inc.

Jacqueline Callihan Linnes

Orlando Sanguinette Hoilett

Megan Zaiyi Chiu

Rui Shen

Hyowon Lee

Ashlyn Twibell

Rohit Srivastava

Ryan Lindsey

Jason D Ummel

Kristin M Byers

Anna Bird

Laura Mae Jamicich

Elizabeth A Phillips

Charles Bruce Matlack

Steven Truitt Wereley

Lee Gehrke

Kimberly Hamad-Schifferli

David K Wood

Jose Gomez-Marquez

Catherine Klapperich

Irene Bosch

Katherine Noel Clayton

Tamara Lea Kinzer-Ursem

Michael S Smith

Donghoon Lee

Taylor Jo Moehling

Natalia M Rodriguez

Tyler Blake Davis

Nevan Clancy Hanumara

Benjamin David Walters

Divya Tankasala

Shubhankar S Takle

Gabriel P Ng

A device for measuring and monitoring heart rate, respiration rate, and oxygen saturation of a subject is disclosed, which includes a biometric sensor board having a photosensor adapted to measure reflectance of red and infrared lights off skin tissue, wherein the biometric sensor board adapted to control one or more light emitting diodes (LEDs), wherein brightness of the LEDs are automatically adjusted to account for skin tone, thereby generating photoplethysmographic data, a processor unit adapted to analyze data measured by the biometric sensor board, and a display adapted to display results of the processed data remotely.

Methods for detecting heart rate, respiration, and oxygen saturation and uses thereof

The present invention relates to a low-cost, thermally reversible valve for paper-fluidic diagnostic devices. In particular, this invention demonstrates a tunable valve mechanism fabricated by wax-ink printing and localized heating via thin-film resistors to sequentially release liquids through a cellulose or nitrocellulose membrane. The wax-ink valve can obstruct fluid flow for a sustained time and are thermally actuated to release a controlled amount of liquid past the valve. This integrated paper-fluidic diagnostic assay device requires minimal user involvement, can be easily manufactured and tuned to meet various fluid delivery timing and incubation needs.

Temperature controlled valves for paper-based microfluidic systems

This invention relates to an improved version of paper-based analytical device and method for chromatographic chemical or immunoassays. Particularly, this present invention discloses a device and a method for reducing smears and improving sharpness and intensity of test sample readout for a multi-step chemical assay or immunoassay by introducing two additional elements, a time-delay pad () and a mixer (), to the conventional two-dimensional paper network device (2DPN).

Fluidic control elements for signal readout enhancement in two-dimensional paper networks (2DPN)

The present disclosure relates to a novel device for selective collection and condensation of an exhaled breath, and the method of using the novel device. The novel device is portable and capable of collecting and condensing reproducible volumes of exhaled breath under about 10 minutes by using a unique temperature-based algorithm.

Device for selective collection and condensation of exhaled breath

This invention generally relates to methods useful for measuring heart rate, respiration conditions, and oxygen saturation and a wearable device that incorporate those methods with a computerized system supporting data collection, analysis, readout and sharing. Particularly this present invention relates to a wearable device, such as a wristwatch or ring, for real time measuring heart rate, respiration conditions, and oxygen saturation.

Method of monitoring respiratory rate in a health monitoring device

This invention relates to a method for measuring viscosity of a fluid using particle diffusometry (PD). The method finds practical applications in detecting structural and functional changes of a biomolecular composition by comparing the viscosity change as compared with the standard of the biomolecular composition. This method may also find uses in clinical diagnosis and quality control of clinical biological medicines, food and feeds during the process of manufacturing, distribution and consumption.

Methods of measuring structural and functional changes of a biomolecular composition

The invention features a fully-integrated rapid molecular diagnostic device that is low-cost, easy to manufacture, and simple to use. The device can serve as a molecular diagnostic platform for any disease, requiring little or no preparation or customization and can be made from simple materials (e.g., paper and adhesive film), making it inexpensive, portable, and disposable. The invention also provides methods of using the device for detection of one or more targets in a sample.

Detection device having capture region and detection region

This invention generally relates to methods useful for measuring heart rate, respiration conditions, and oxygen saturation and a wearable device that incorporate those methods with a computerized system supporting data collection, analysis, readout and sharing. Particularly this present invention relates to a wearable device, such as a wrist watch or ring, for real time measuring heart rate, respiration conditions, and oxygen saturation.

A system for solar disinfection of fluid. One most preferred version of the system includes: Alternative embodiments may also include sensors to detect additional characteristics, such as transmittance, turbidity, 'combined transmittance,' and/or temperature.

Solar disinfection of fluid

Exemplary embodiments provide diagnostic devices, systems and methods for determining the presence or absence of one or more markers or characteristics in one or more samples. An exemplary diagnostic device may display a first two-dimensional machine-readable output to indicate the presence or absence of a first characteristic in a sample. Similarly, the exemplary diagnostic device may display a second two-dimensional machine-readable output to indicate the presence or absence of a second characteristic in a sample. An image capture device may be used to automatically detect the two-dimensional machine-readable output appearing in the diagnostic device. A computational device may be used to automatically determine whether the presence or absence of the first characteristic and/or the second characteristic based on the two-dimensional machine-readable output displayed in the diagnostic device.

Systems, devices and methods for multiplexed diagnostics

Growing community of inventors

West Lafayette, IN, United States of America

Jacqueline Callihan Linnes