Ivan Guryanov

Title: Ivan Guryanov: Innovator in Peptide Manufacturing

Introduction

Ivan Guryanov is a notable inventor based in Villadose, Italy. He has made significant contributions to the field of peptide manufacturing, holding a total of 3 patents. His work focuses on innovative processes that enhance the production of important pharmaceutical compounds.

Latest Patents

Guryanov's latest patents include a process for the manufacture of degarelix and its intermediates. This invention provides a manufacturing process for preparing a peptide, preferably a decapeptide, such as degarelix, by incorporating p-nitro-phenylalanin in the amino acid sequence during stepwise solid phase synthesis. The invention also details the conversion of these into the required amino acids Aph(Hor) and/or D-Aph(Cbm), preferably while attached to a solid phase. Additionally, he has developed a process for the manufacture of GLP-1 analogues. This process achieves high yield and purity through fragment condensation on the solid phase, describing a convergent synthesis by condensation of a C-terminal pseudoproline fragment A with a fragment B bound to a solid support.

Career Highlights

Ivan Guryanov is currently employed at Fresenius Kabi Ipsum S.r.l., where he continues to innovate in the field of peptide synthesis. His expertise and dedication to research have positioned him as a key figure in his organization.

Collaborations

Guryanov collaborates with esteemed colleagues, including Antonio Ricci and Walter Cabri, who contribute to his research endeavors and enhance the collaborative environment within his workplace.

Conclusion

Ivan Guryanov's contributions to peptide manufacturing through his innovative patents and collaborative efforts highlight his importance in the pharmaceutical industry. His work continues to pave the way for advancements in peptide synthesis and related fields.