The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 26, 2022
Filed:
Oct. 09, 2019
Fresenius Kabi Ipsum S.r.l., Cassina de' Pecchi—Milano, IT;
Giuseppina Maria Incisivo, Villadose, IT;
Andrea Orlandin, Villadose, IT;
Antonio Ricci, Villadose, IT;
Ivan Guryanov, Villadose, IT;
Walter Cabri, Villadose, IT;
FRESENIUS KABI IPSUM S.R.L., Milan, IT;
Abstract
The present invention provides a process for the manufacture of GLP-1 analogues with high yield and purity by fragment condensation on the solid phase. In particular, it describes a convergent synthesis by condensation of a C-terminal pseudoproline fragment A with a fragment B bound to a solid support, followed by deprotection and cleavage from the support and final purification to yield the desired peptide. The invention further provides intermediates useful in the manufacturing process.