The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 2021
Filed:
Dec. 19, 2016
Fresenius Kabi Ipsum S.r.l, Milan, IT;
Antonio Ricci, Milan, IT;
Jacopo Zanon, Milan, IT;
Walter Cabri, Milan, IT;
Ivan Guryanov, Padua, IT;
Andrea Orlandin, Cazarzere, IT;
Barbara Biondi, Venezia-Mestre, IT;
Fernando Formaggio, Noventa Vicentina, IT;
Dario Visentini, Villadose, IT;
FRESENIUS KABI IPSUM S.R.L, Milan, IT;
Abstract
The present invention provides a manufacturing process for preparing a peptide, preferably a decapeptide, such as degarelix, by incorporating p-nitro-phenylalanin in the amino acid sequence preferably during stepwise solid phase synthesis, and converting these into the required amino acids Aph(Hor) and/or D-Aph(Cbm), preferably while attached to a solid phase. The invention further provides intermediates useful in the manufacturing process.