Company Filing History:
Years Active: 2022-2024
Title: Innovations of Iti Saraav in Toxoplasma Research
Introduction
Iti Saraav is a notable inventor based in St. Louis, MO (US). He has made significant contributions to the field of immunology, particularly in the detection of toxoplasma infections. With a total of 3 patents, his work has advanced the understanding of cellular immunity and its applications in medical testing.
Latest Patents
One of Iti Saraav's latest patents focuses on antigens for detecting toxoplasma infection by monitoring cellular immunity. This invention utilizes antigens that provide a specific and strong delayed type hypersensitivity (DTH) immune response, or stimulate IFN-γ secretion, to test subjects for infection. Various skin testing formats, such as patches, needles, or prongs, can be adapted for this purpose. The presence of DTH indicates an infection. Another significant patent involves immunologically active fragments of Toxoplasma gondii. The proteins MIC1 and MIC4 are components of excretory/secretory antigens (ESA) that elicit DTH responses in infected animals. These antigens can induce IFN-γ secretion by splenic T cells, stimulate T cells to produce cytokines that recruit inflammatory monocytes and neutrophils, and result in a positive luminol test.
Career Highlights
Iti Saraav is affiliated with Washington University, where he conducts his research and develops his innovative patents. His work has been instrumental in enhancing the methods used for detecting toxoplasma infections, thereby contributing to public health.
Collaborations
Iti collaborates with esteemed colleagues, including Laurence David Sibley and Qiuling Wang, to further his research and expand the impact of his inventions.
Conclusion
Iti Saraav's contributions to the field of immunology through his patents on toxoplasma detection are noteworthy. His innovative approaches are paving the way for improved diagnostic methods and better understanding of immune responses.