The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2024
Filed:
Aug. 19, 2020
Applicant:
Washington University, St. Louis, MO (US);
Inventors:
Laurence David Sibley, St. Louis, MO (US);
Iti Saraav, St. Louis, MO (US);
Qiuling Wang, St. Louis, MO (US);
Mary Savari Dhason, St. Louis, MO (US);
Assignee:
Washington University, St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/002 (2006.01); A61K 39/00 (2006.01); A61P 33/02 (2006.01); C07K 14/45 (2006.01); C07K 16/20 (2006.01);
U.S. Cl.
CPC ...
A61K 39/002 (2013.01); A61P 33/02 (2018.01); C07K 14/45 (2013.01); C07K 16/20 (2013.01); A61K 2039/54 (2013.01); A61K 2039/57 (2013.01);
Abstract
proteins MIC1 and MIC4 are components of excretory/secretory antigens (ESA) that elicit delayed type hypersensitivity (DTH) responses in infected animals. These antigens are capable of inducing IFN-g secretion by splenic T cells (ELISPOT assay), stimulating T cells to produce cytokines that recruit inflammatory monocytes and neutrophils resulting in a positive luminol test (luminol ear assay), and eliciting a positive skin test in the guinea pig.