Hye Ji Choi

Title: Hye Ji Choi: Innovator in Recombinant Technology

Introduction

Hye Ji Choi is a prominent inventor based in Jeollanam-do, South Korea. He has made significant contributions to the field of biotechnology, particularly in the development of recombinant vectors and methods for producing essential proteins.

Latest Patents

Hye Ji Choi holds two notable patents. The first patent is for a recombinant vector and method for producing recombinant fibroblast growth factor 19 (FGF19). This invention enhances the solubility of FGF19 by allowing the simultaneous and independent expression of a synonymous codon substitution variant fibroblast growth factor 19 and chaperone ssDsbC in a host cell. This method enables the overexpression of FGF19 in a soluble state, which is crucial for various therapeutic applications. The second patent involves a recombinant vector and method for producing a reconstituted cytochrome P450 oxygenase-reductase fusion protein. This invention allows for the independent expression of oxygenase and reductase in a host cell, which can then be fused with a split intein. This process increases the heme content in the active site of the oxygenase, thereby improving enzyme activity and stability.

Career Highlights

Hye Ji Choi has worked at esteemed institutions such as Chonnam National University and the Korea Institute of Ocean Science & Technology. His work at these organizations has allowed him to advance his research and contribute to the scientific community significantly.

Collaborations

Throughout his career, Hye Ji Choi has collaborated with notable colleagues, including Geun Joong Kim and Dae Eun Cheong. These collaborations have further enriched his research and innovation efforts.

Conclusion

Hye Ji Choi is a distinguished inventor whose work in recombinant technology has the potential to impact various fields, including medicine and biotechnology. His patents reflect his commitment to advancing scientific knowledge and improving protein production methods.