Chonnam National University

Korea Institute of Ocean Science & Technology

Hye Ji Choi

Geun Joong Kim

Dae Eun Cheong

Su Kyoung Yoo

Dong Hyun Lee

Jung Hyun Lee

Chul Ho Yun

Young Jun An

Kyeong Won Lee

Hyung Soon Yim

Jae Hong Park

Thien Kim Le

A recombinant vector according to an embodiment of the present invention may produce fibroblast growth factor 19 (FGF19) having enhanced solubility. The synonymous codon substitution variant fibroblast growth factor 19 (scvhFGF19) and chaperone &#x394;ssDsbC may be simultaneously and independently expressed in a host cell into which the recombinant vector is introduced, thereby it is possible to overexpress the fibroblast growth factor 19 in a soluble state.

Recombinant vector and method for producing recombinant fibroblast growth factor 19 using the same

A recombinant vector according to an embodiment of the present invention may be used for producing a reconstituted cytochrome P450 oxygenase-reductase fusion protein. Oxygenase and reductase may be independently expressed in a host cell into which the recombinant vector is introduced, and then may be fused with a split intein so that it is possible to increase the heme content contained in the active site of the oxygenase and improve enzyme activity and stability.

Recombinant vector and method for producing reconstituted cytochrome P450 oxygenase-reductase fusion protein using the same

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Jeollanam-do, South Korea

Hye Ji Choi