Company Filing History:
Years Active: 2011-2024
Title: Hisahiro Tabuchi: Innovator in Recombinant Protein Production
Introduction
Hisahiro Tabuchi is a prominent inventor based in Tokyo, Japan. He has made significant contributions to the field of biotechnology, particularly in the area of recombinant protein production. With a total of 13 patents to his name, Tabuchi's work has advanced the methods used in producing proteins through cultured animal cells.
Latest Patents
Among his latest patents, Tabuchi has developed a recombinant polypeptide production method. This innovative method allows for the high-level production of proteins by culturing cells that express the Antibody Production Enhancing Sequence (APES). The process involves introducing DNA encoding a desired polypeptide into these cells, which contain a nucleotide sequence related to nuclear factor κB inhibitor α (NfkBia). This method effectively decreases the intracellular expression of NfkBia, enhancing protein production.
Another notable patent is the method for establishing a modified host cell. This invention aims to create a stable cell line that can be used for recombinant protein production. The method involves transferring a gene of a non-coding RNA that suppresses the expression of NfkBia to a cell, allowing for the stable expression of two or more foreign genes.
Career Highlights
Tabuchi is currently associated with Chugai Seiyaku Kabushiki Kaisha, a leading pharmaceutical company in Japan. His work at Chugai has been instrumental in developing advanced biotechnological solutions that address various medical needs. His expertise in recombinant protein production has positioned him as a key figure in the industry.
Collaborations
Throughout his career, Tabuchi has collaborated with several talented individuals, including Tomoya Sugiyama and Satoshi Tainaka. These collaborations have fostered innovation and have contributed to the successful development of his patented technologies.
Conclusion
Hisahiro Tabuchi's contributions to the field of biotechnology, particularly in recombinant protein production, have made a significant impact. His innovative methods and collaborations continue to advance the industry, showcasing his dedication to scientific progress.