The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2024
Filed:
Apr. 23, 2021
Applicant:
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Inventors:
Hisahiro Tabuchi, Tokyo, JP;
Tomoya Sugiyama, Tokyo, JP;
Assignee:
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01); C07K 16/30 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/00 (2013.01); C12N 15/113 (2013.01); A61K 38/00 (2013.01); C07K 16/2866 (2013.01); C07K 16/303 (2013.01); C07K 2317/14 (2013.01); C12N 2310/14 (2013.01); C12N 2510/02 (2013.01);
Abstract
Provided is a method capable of producing a protein at a high level using a cultured animal cell, comprising culturing a cell that expresses APES (Antibody Production Enhancing Sequence) and into which a DNA encoding a desired polypeptide has been introduced, thereby producing the desired polypeptide. APES contains a nucleotide sequence related to nuclear factor κB inhibitor α (NfkBia) and has a function of decreasing the intracellular expression of NfkBia.