Location History:
- Chiba-ken, JP (1998 - 2000)
- Chiba, JP (1992 - 2002)
Company Filing History:
5 out of 1,788 
1 out of 2,272 
1 out of 1,379 
Years Active: 1992-2002
Title: Hiroshi Uchida: Innovator in Human Growth Hormone Production
Introduction
Hiroshi Uchida is a prominent inventor based in Chiba, Japan. He has made significant contributions to the field of biotechnology, particularly in the production of human growth hormone (hGH). With a total of 7 patents to his name, Uchida's work has paved the way for advancements in medical and pharmaceutical applications.
Latest Patents
Uchida's latest patents focus on methods for the secretory production of human growth hormone. One notable patent describes a process where a DNA encoding 20K hGH is directly connected to a gene encoding the OppA protein secretion signal, along with a DNA encoding signal peptidase 1. This recombinant plasmid is transformed into cells, allowing for the efficient secretory production of 20K hGH in the periplasm. This method not only enhances the production efficiency but also simplifies the isolation and purification of 20K hGH due to the low level of impure proteins present in the periplasm fraction.
Another patent outlines a similar method using Escherichia coli, where the DNA encoding 20K hGH is linked to the OppA protein secretion signal. The resulting E. coli transformant strain is cultured for the secretory production of 20K hGH in the E. coli periplasm. This innovative approach also facilitates easy isolation and purification of the hormone, further demonstrating Uchida's expertise in biotechnological advancements.
Career Highlights
Throughout his career, Hiroshi Uchida has worked with notable companies such as Mitsui Chemicals, Inc. and Idemitsu Kosan Company, Limited. His experience in these organizations has contributed to his understanding and development of innovative biotechnological processes.
Collaborations
Uchida has collaborated with esteemed colleagues, including Masaru Honjo and Naokazu Naitoh. These partnerships have likely enriched his research and led to further advancements in his field.
Conclusion
Hiroshi Uchida's contributions to the production of human growth hormone through innovative methods have established him as a key figure in biotechnology. His patents reflect a commitment to enhancing efficiency and purity in hormone production, which has significant implications for medical science.