Location History:
- Osaka, JP (2007 - 2014)
- Shinagawa-ku, JP (2021)
Company Filing History:
3 out of 440 
2 out of 19 
1 out of 1 Years Active: 2007-2021
Title: Hidenobu Murafuji: Innovator in Pharmaceutical Chemistry
Introduction
Hidenobu Murafuji is a prominent inventor based in Osaka, Japan. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the development of compounds for treating various diseases. With a total of six patents to his name, Murafuji's work focuses on innovative solutions for complex medical conditions.
Latest Patents
Among his latest patents, Murafuji has developed a pyrimidine derivative aimed at treating cystic fibrosis. This condition arises from mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR), a type of chloride channel. The objective of this invention is to provide compounds that effectively open a chloride channel distinct from CFTR, thereby offering a new therapeutic approach. The compounds are designed to activate calcium-dependent chloride channels (CaCCs) through G-protein coupled receptor 39 (GPR39) agonism, resulting in a strong chloride ion-secretory action.
Additionally, Murafuji has created thienopyrazole derivatives that selectively inhibit phosphodiesterase 7 (PDE7). This inhibition enhances cellular cAMP levels, making these compounds useful for treating a variety of diseases, including allergic, inflammatory, and immunologic conditions. The thienopyrazole compounds are represented by specific chemical formulas that detail their structure and functional groups.
Career Highlights
Hidenobu Murafuji has worked with notable companies in the pharmaceutical industry, including Daiichi Sankyo Company, Limited and Asubio Pharma Co. Ltd. His experience in these organizations has allowed him to refine his expertise in drug development and innovation.
Collaborations
Throughout his career, Murafuji has collaborated with esteemed colleagues such as Hidekazu Inoue and Yasuhiro Hayashi. These partnerships have contributed to the advancement of his research and the successful development of his patented compounds.
Conclusion
Hidenobu Murafuji is a distinguished inventor whose work in pharmaceutical chemistry has the potential to transform treatment options for various diseases. His innovative patents reflect a commitment to addressing complex medical challenges through scientific research and collaboration.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.