The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 15, 2021
Filed:
Dec. 26, 2017
Daiichi Sankyo Company, Limited, Tokyo, JP;
Yasuyuki Takeda, Funabashi, JP;
Yamato Suzuki, Shinagawa-ku, JP;
Toshiharu Noji, Ota-ku, JP;
Hidenobu Murafuji, Shinagawa-ku, JP;
Satoshi Muneoka, Shinagawa-ku, JP;
Hidekazu Inoue, Ota-ku, JP;
Bitoku Takahashi, Shinagawa-ku, JP;
Rie Inaba, Ota-ku, JP;
Daiichi Sankyo Company, Limited, Tokyo, JP;
Abstract
Cystic fibrosis is developed through mutation of Cystic Fibrosis Transmembrane conductance Regulator (CFTR), which is one type of chloride channel. An object of the present invention is to provide compounds effective in the treatment of cystic fibrosis that open a chloride channel different from CFTR, which is the cause of the disease, and do not depend on CFTR. Compounds of the present invention are compounds or pharmaceutically acceptable salts thereof that open calcium dependent chloride channels (CaCCs) via G-protein coupled receptor 39 (GPR39) agonism to have strong chloride ion-secretory action, and are represented by the following general formula (I): General formula (I): wherein,