Helena Domingues

Title: Helena Domingues: Innovator in Cytokine Research

Introduction

Helena Domingues is a prominent inventor based in Heidelberg, Germany. She has made significant contributions to the field of cytokine research, holding 2 patents that focus on the stabilization and design of cytokines and their antagonists. Her work has implications for pharmaceutical applications and advances in molecular biology.

Latest Patents

One of her latest patents is titled "Modified cytokine." This invention relates to methods for the stabilization of cytokines and to cytokines generated by such methods. The methods involve mutating the amino acid sequence of a cytokine to remove solvent-exposed hydrophobic residues and stabilizing one or more secondary structure elements in the molecule. These modifications help to destabilize intermediates formed during the folding process, thereby increasing the yield of the cytokine produced in vitro. Another significant patent is "Coiled-coil dimer derived antagonists of 4-helix bundle cytokines, design and uses thereof." This patent discloses the design of antagonists for specific receptors of 4-helix bundle cytokines, including mimetic peptides that can act as pharmaceutical agents.

Career Highlights

Helena has worked with esteemed organizations such as the European Molecular Biology Laboratory and Bayer Aktiengesellschaft. Her experience in these institutions has allowed her to develop her expertise in molecular biology and cytokine research.

Collaborations

Throughout her career, Helena has collaborated with notable scientists, including Hartmut Oschkinat and Luis Serrano. These collaborations have enriched her research and contributed to her innovative work in the field.

Conclusion

Helena Domingues is a trailblazer in cytokine research, with her patents paving the way for advancements in therapeutic applications. Her contributions to the scientific community continue to inspire future innovations in molecular biology.