Bayer Aktiengesellschaft

European Molecular Biology Laboratory

Europaisches Laboratorium Molekularbiologie

Helena Domingues

Hartmut Oschkinat

Luis Serrano

Walter Sebald

Joerg Peters

David Cregut

The invention relates to methods for the stabilisation of cytokines and to cytokines generated by such methods. The methods of the invention involve mutating the amino acid sequence of a cytokine so as to remove solvent-exposed hydrophobic residues, and/or mutating the amino acid sequence of the cytokine so as to stabilise one or more secondary structure elements in the molecule. These steps have the effect of destabilsing intermediates that are formed during the folding process, relative to the stability of the cytokine in its naturally folded state, so increasing the yield of the cytokine as produced in vitro.

Modified cytokine

The design of antagonists of 4-helix bundle cytokine specific receptors, mimetic peptides that are able to act as such antagonists and their use as pharmaceutical agents is disclosed.

Coiled-coil dimer derived antagonists of 4-helix bundle cytokines, design and uses thereof

Growing community of inventors

Heidelberg, Germany

Helena Domingues