Company Filing History:
Years Active: 2008-2011
Title: The Innovations of Hans-Joachim Gaus
Introduction
Hans-Joachim Gaus is a notable inventor based in Carlsbad, California. He has made significant contributions to the field of oligonucleotide synthesis and analysis. With a total of 3 patents, Gaus has developed innovative methods that enhance the detection and quantification of impurities in oligonucleotides.
Latest Patents
One of Gaus's latest patents is titled "Methods for detection, identification and quantification of impurities." This method involves introducing a sample containing a plurality of oligonucleotides into an ion pair high-performance liquid chromatography column. The process allows for the separation of oligonucleotides, which are then quantified using mass spectrometry. Notably, the method ensures that at least 50 mole percent of co-eluting oligonucleotides have the same charge when entering the mass spectrometer.
Another significant patent is "Chloral-free DCA in oligonucleotide synthesis." This process focuses on manufacturing oligonucleotides through a 5'-deblocking step, utilizing dichloroacetic acid that is essentially free of chloral. This innovation is particularly useful for producing oligonucleotides that are substantially free of chloral adducts.
Career Highlights
Hans-Joachim Gaus is currently associated with Isis Pharmaceuticals, Inc., where he continues to advance his research and development efforts. His work has been instrumental in improving the quality and safety of oligonucleotide products.
Collaborations
Throughout his career, Gaus has collaborated with several esteemed colleagues, including Daniel C. Capaldi and Christine C. Kurata. These collaborations have further enriched his research and contributed to the success of his innovative projects.
Conclusion
Hans-Joachim Gaus is a distinguished inventor whose work in oligonucleotide synthesis and analysis has led to significant advancements in the field. His innovative patents reflect his commitment to improving scientific methodologies and enhancing product quality.
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