The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 2010
Filed:
Jan. 29, 2007
Applicants:
Achim Krotz, San Diego, CA (US);
Daniel C. Capaldi, Carlsbad, CA (US);
Hans-joachim Josef Gaus, Carlsbad, CA (US);
Brett Turney, San Diego, CA (US);
Inventors:
Achim Krotz, San Diego, CA (US);
Daniel C. Capaldi, Carlsbad, CA (US);
Hans-Joachim Josef Gaus, Carlsbad, CA (US);
Brett Turney, San Diego, CA (US);
Assignee:
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
A process of manufacturing oligonucleotides includes a 5'-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is useful for making oligonucleotides that are substantially free of chloral adducts.