Company Filing History:
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1 out of 16 
1 out of 1 Years Active: 2003-2023
Title: Gerhard Jas: Innovator in Biochemical Synthesis
Introduction
Gerhard Jas is a prominent inventor based in Berlin, Germany, known for his significant contributions to the field of biochemical synthesis. With a remarkable portfolio that includes four patents, his innovations focus on advanced methodologies for synthesizing critical compounds in pharmaceuticals.
Latest Patents
Among his latest patents, Gerhard Jas has developed an innovative method for synthesizing (2S,3R,4R)-4,5-dihydroxyisoleucine and its derivatives. This invention outlines a comprehensive process that begins with the asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester, followed by the kinetic resolution of the product diastereomer mix through acylase. Furthermore, the process culminates with the Sharpless dihydroxylation of the resulting 2-amino-3-methylpent-4-enoic acid derivative. Another noteworthy patent describes the most effective approach for the base-free preparation of ketone intermediates, which are essential for the manufacture of the antihypertensive drug nebivolol. This process includes the activation of a carboxylic acid using a peptide coupling agent, coupling with a malonic acid derivative to produce a β-ketoester precursor, and finally converting this precursor into a ketone of a general formula.
Career Highlights
Gerhard Jas has contributed his expertise to notable companies, including C-chem AG and Cordon Pharma International GmbH. His work in these organizations has facilitated advancements in chemical research and development, enhancing the production of vital pharmaceutical compounds.
Collaborations
Throughout his career, Gerhard Jas has collaborated with esteemed colleagues such as Ilia Freifeld and Kurt Kesseler. These partnerships have enriched his research and led to further innovations in the biochemical field.
Conclusion
With a robust portfolio of patents and a career marked by collaboration and innovation, Gerhard Jas stands out as a leading figure in the realm of biochemical synthesis. His work not only contributes to scientific advancements but also plays a crucial role in developing important pharmaceutical applications.