The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 26, 2018
Filed:
Feb. 13, 2015
Applicant:
Cordon Pharma International Gmbh, Plankstadt, DE;
Inventors:
Ilia Freifeld, Bad Vilbel, DE;
Gerhard Jas, Berlin, DE;
Kurt Kesseler, Hofheim, DE;
Richard Robert Dauer, Longmont, CO (US);
Assignee:
CORDON PHARMA INTERNATIONAL GMBH, Lankstadt, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 311/58 (2006.01);
U.S. Cl.
CPC ...
C07D 311/58 (2013.01);
Abstract
The invention relates to a process for the preparation of a ketone of a general formula 1 with X being Cl or Br, in particular with X being Cl, with Y being F, Cl, Br, I or H, in particular with Y being F,comprising the steps of: activation of a carboxylic acid by using a peptide coupling agent, coupling of the activated carboxylic acid with a malonic acid derivative providing a β-ketoester precursor and converting the β-ketoester precursor to the ketone of the general formula 1.