The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2023
Filed:
Mar. 29, 2019
Applicant:
Heidelberg Pharma Research Gmbh, Ladenburg, DE;
Inventors:
Caroline Knittel, Berlin, DE;
Mary-Ann Siegert, Berlin, DE;
Roderich Süssmuth, Berlin, DE;
Christoph Wink, Kelkheim, DE;
Gerhard Jas, Berlin, DE;
Assignee:
Heidelberg Pharma Research GmbH, Ladenburg, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 227/16 (2006.01); C07C 229/30 (2006.01); C07D 319/20 (2006.01); C07D 493/10 (2006.01); C07D 493/20 (2006.01); A61K 31/439 (2006.01); B01J 21/06 (2006.01); C07F 7/18 (2006.01);
U.S. Cl.
CPC ...
C07C 227/16 (2013.01); A61K 31/439 (2013.01); B01J 21/063 (2013.01); C07D 319/20 (2013.01); C07D 493/10 (2013.01); C07D 493/20 (2013.01); C07F 7/1804 (2013.01); C07C 229/30 (2013.01);
Abstract
The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diastereomer mix by acylase, and subsequent Sharpless dihydroxylation of the resulting 2-amino-3-methylpent-4-enoic acid derivative.