Location History:
- Blain, TN (US) (2000 - 2004)
- Knoxville, TN (US) (2005)
- Blaine, TN (US) (1988 - 2021)
Company Filing History:
6 out of 764 
5 out of 1,618 
2 out of 2,002 
Years Active: 1988-2021
Title: Innovations of Gary S Sayler
Introduction
Gary S Sayler is a prominent inventor based in Blaine, Tennessee, known for his significant contributions to the field of bioluminescence and cellular engineering. With a total of 16 patents to his name, Sayler has made remarkable advancements that have implications in various scientific and medical applications.
Latest Patents
Among his latest patents is the invention titled "Lux expression in cells and methods of use." This patent describes cells, including stem cells, that possess an autobioluminescent phenotype, allowing them to emit a luminescent signal without the need for an external luminescent stimulator. The luminescent signal can be constitutive, inducible, repressible, or tissue-specific. The cells are engineered to express a synthetic bacterial luciferase (lux) cassette, specifically the luxCDABEfrp gene cassette. Notably, these cells can express a combined level of luxC, luxD, luxE, and flavin reductase that is significantly higher than that of luxA and luxB. Additionally, he has developed a patent for a "Microluminometer chip and method to measure bioluminescence." This invention features an integrated microluminometer that includes a photodetector for converting light into a photocurrent, enhancing measurement efficiency through a distributed electrode configuration.
Career Highlights
Gary S Sayler has had a distinguished career, working with notable organizations such as the University of Tennessee Research Foundation and UT-Battelle, Inc. His work has focused on innovative solutions that bridge the gap between biology and technology, particularly in the realm of bioluminescent applications.
Collaborations
Throughout his career, Sayler has collaborated with esteemed colleagues, including Steven Ripp and Michael Leon Simpson. These partnerships have fostered a collaborative environment that has led to groundbreaking research and development in his field.
Conclusion
Gary S Sayler's contributions to the field of bioluminescence and cellular engineering are noteworthy, with a portfolio of patents that reflect his innovative spirit and dedication to scientific advancement. His work continues to influence research and applications in various domains.