Frederick M Hughson

Title: Innovations of Frederick M Hughson

Introduction

Frederick M Hughson is a notable inventor based in Princeton, NJ (US). He has made significant contributions to the field of drug discovery through his innovative research and patents. With a total of 2 patents, Hughson's work focuses on the structural analysis of crystals and their applications in pharmaceutical compositions.

Latest Patents

Hughson's latest patents include groundbreaking inventions related to crystals comprising apo-LsrB and holo-LsrB. This invention identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule. The X-ray crystallographic data obtained can be utilized in drug discovery methods. Additionally, the invention provides AI-2 analogs based on this discovery, along with pharmaceutical compositions containing those analogs. Another significant patent involves the crystals of LuxP and complexes thereof, where a binding site for autoinducer-2 (AI-2) is identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in drug discovery methods, with pharmaceutical compositions comprising ligands identified by such methods aimed at treating bacterial infections.

Career Highlights

Frederick M Hughson is affiliated with Princeton University, where he conducts his research and development. His work has garnered attention for its potential impact on drug discovery and treatment methodologies.

Collaborations

Hughson collaborates with esteemed colleagues such as Bonnie L Bassler and Stephen T Miller, contributing to a rich environment of innovation and research.

Conclusion

Frederick M Hughson's contributions to the field of drug discovery through his patents and collaborations highlight his role as a significant inventor in the scientific community. His work continues to pave the way for advancements in pharmaceutical applications.