The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 24, 2007
Filed:
Aug. 22, 2002
Applicants:
Bonnie L. Bassler, Princeton, NJ (US);
Stephan Schauder, Lyons, FR;
Xin Chen, Edison, NJ (US);
Frederick M. Hughson, Princeton, NJ (US);
Stephen R. Cooper, Carlsbad, CA (US);
Inventors:
Bonnie L. Bassler, Princeton, NJ (US);
Stephan Schauder, Lyons, FR;
Xin Chen, Edison, NJ (US);
Frederick M. Hughson, Princeton, NJ (US);
Stephen R. Cooper, Carlsbad, CA (US);
Assignee:
Princeton University, Princeton, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 307/94 (2006.01); A01N 43/30 (2006.01);
U.S. Cl.
CPC ...
Abstract
A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identified by such drug discovery methods are used to treat bacterial infections.