The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2009
Filed:
Sep. 16, 2005
Stephen T. Miller, Swarthmore, PA (US);
Karina B. Xavier, Princeton, NJ (US);
Michiko E. Taga, Somerville, MA (US);
Shawn R. Campagna, Hamilton, NJ (US);
Martin F. Semmelhack, Princeton, NJ (US);
Bonnie L. Bassler, Princeton, NJ (US);
Frederick M. Hughson, Princeton, NJ (US);
Stephen T. Miller, Swarthmore, PA (US);
Karina B. Xavier, Princeton, NJ (US);
Michiko E. Taga, Somerville, MA (US);
Shawn R. Campagna, Hamilton, NJ (US);
Martin F. Semmelhack, Princeton, NJ (US);
Bonnie L. Bassler, Princeton, NJ (US);
Frederick M. Hughson, Princeton, NJ (US);
The Trustees of Princeton University, Princeton, NJ (US);
Abstract
This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.