Location History:
- Merion, PA (US) (1992)
- Merion Station, PA (US) (1993)
Company Filing History:
Years Active: 1992-1993
Title: Frederick A. Golec: Innovator in Pharmaceutical Chemistry
Introduction
Frederick A. Golec is a notable inventor based in Merion, PA, who has made significant contributions to the field of pharmaceutical chemistry. With a total of 2 patents, his work focuses on the synthesis of compounds that have important applications in medical science.
Latest Patents
Golec's latest patents include innovative processes that enhance the preparation and purification of complex chemical compounds. One of his notable inventions is the "Asymmetric synthesis of hexahydrodibenzofurans by stereospecific." This invention relates to a stereospecific process for the preparation, separation, and purification of hexahydrodibenzofurans, which are crucial in the development of 5HT₃ compounds. The process involves the acidic catalyzed stereospecific ring closure by the intra-molecular inversion of a gamma carbon atom of a specific phenol compound.
Another significant patent is the "Process for the preparation of optically pure amides." This invention focuses on certain dibenzofurancarboxamides and their use as 5HT₃ antagonists, which exhibit unique central nervous system (CNS) activity, anti-emetic properties, and gastric prokinetic activity without significant D₂ receptor binding. This process also includes the synthesis of stereoisomeric compounds with similar beneficial activities.
Career Highlights
Frederick A. Golec has been associated with Rhone-Poulenc Rorer Pharmaceuticals Inc., where he has contributed to various innovative projects in pharmaceutical development. His expertise in chemical synthesis and process optimization has been instrumental in advancing the company's research initiatives.
Collaborations
Throughout his career, Golec has collaborated with notable colleagues, including Matthew R. Powers and Raymond D. Youssefyeh. These collaborations have fostered a productive environment for innovation and have led to the successful development of new pharmaceutical compounds.
Conclusion
Frederick A. Golec's contributions to pharmaceutical chemistry through his patents and collaborative efforts highlight his role as an influential inventor in the field. His work continues to impact the development of important medical compounds that benefit society.