The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 27, 1993
Filed:
Jul. 06, 1992
Applicant:
Inventors:
Mattew R Powers, Barto, PA (US);
Frederick A Golec, Merion Station, PA (US);
Assignee:
Rhone-Poulenc Rorer Pharmaceuticals Inc., Collegeville, PA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; C12P / ;
U.S. Cl.
CPC ...
549461 ; 435126 ;
Abstract
This invention relates to the stereospecific process for the preparation, separation and purification of hexahydrodibenzofurans which are used in the preparation of the 5HT.sub.3 compounds. More specifically, the present invention relates to a process for the preparation of substantially optically pure cishexahydrodibenzofuran compounds including at least two chiral fused ring centers which comprises the acidic catalyzed stereospecific ring closure by the intra-molecular inversion of a gamma, i.e. 2', carbon atom of a 2-[(2'-leaving group)cycloalkyl]phenol.