Franz Hartner

Title: **Innovations of Franz Hartner: Pioneering Fermentation Processes for Antibody Production**

Introduction

Franz Hartner, an inventor based in Kundl, Austria, has made significant contributions to the field of biotechnology through his innovative work in fermentation processes. With a portfolio of five patents, Hartner has focused on developing efficient methods for producing recombinant proteins, particularly antibodies, by enhancing fermentation techniques.

Latest Patents

Hartner's latest patents showcase his expertise in fermentation and protein production. One notable patent details a fermentation process for antibody production featuring a feedback control mechanism. This mechanism employs a respiratory quotient measurement to optimize levels of oxygenation and fermentation sugar feed, resulting in well-controlled cultures. These cultures not only yield substantial amounts of product but also prevent the toxic accumulation of ethanol. The recombinant proteins produced through this method exhibit excellent qualitative properties, ensuring homogeneity and proper inter-subunit assembly.

Another of his recent patents encompasses methods for producing heterologous proteins, particularly focusing on multi-subunit proteins like antibodies. The improvements outlined in this patent promise higher yield and enhanced purity, which are critical for pharmaceutical applications. The methods involve transforming cells, specifically utilizing yeast such as methylotrophic yeast, to achieve these outcomes.

Career Highlights

Hartner has worked with organizations like Alderbio Holdings LLC and H. Lundbeck A/S, where his research and development efforts have led to significant advancements in biopharmaceutical manufacturing processes. His drive to innovate has positioned him as a key figure in the biotechnology sector.

Collaborations

Throughout his career, Hartner has collaborated with esteemed colleagues such as Gary Lesnicki and Patricia Dianne McNeill. These collaborations have played a crucial role in the technical advancements and successful implementation of his inventive ideas in the production of complex proteins.

Conclusion

Franz Hartner stands out as a prominent inventor in the biotechnology arena, particularly for his contributions to fermentation processes and protein production. His work not only showcases innovation through patents but also highlights the importance of collaboration in advancing scientific knowledge. Through his efforts, Hartner continues to influence the field, paving the way for new discoveries and applications in biopharmaceuticals.