The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2023
Filed:
Jan. 25, 2019
Applicant:
H. Lundbeck A/s, Valby, DK;
Inventors:
Gary Lesnicki, Woodinville, WA (US);
Patricia Dianne McNeill, Federal Way, WA (US);
Franz Hartner, Kundl, AT;
Mark Young, Boulder, CO (US);
Assignee:
H. LUNDBECK A/S, Valby, DK;
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C12P 21/02 (2006.01); C12P 21/00 (2006.01); C12N 15/63 (2006.01); C12N 15/67 (2006.01); C12N 15/81 (2006.01);
U.S. Cl.
CPC ...
C07K 16/00 (2013.01); C12P 21/00 (2013.01); C12P 21/02 (2013.01); C07K 2317/14 (2013.01); C12N 15/63 (2013.01); C12N 15/67 (2013.01); C12N 15/815 (2013.01);
Abstract
A feedback control mechanism for a fermentation of yeast cells to make recombinant proteins uses a respiratory quotient measurement which adjusts the levels of oxygenation and/or fermentable sugar feed. The feedback control mechanism permits well controlled cultures that produce good amounts of product while avoiding toxic accumulation of ethanol. Additionally, recombinant proteins so produced have excellent qualitative properties, such as excellent homogeneity and proper inter-subunit assembly.