Francis S Markland, Jr

Title: **Innovations of Francis S. Markland, Jr. in Biocompatible Implants and Protein Expression**

Introduction

Francis S. Markland, Jr., a prominent inventor based in Manhattan Beach, California, is recognized for his significant contributions to the field of biomedical innovations. With a total of 16 patents to his name, Markland's work focuses primarily on biocompatible implants and advanced methods for protein expression. His inventions have the potential to greatly impact medical treatments and research.

Latest Patents

Among his latest patents, the invention of biocompatible silicone implants stands out. This innovative implant can be securely affixed to living tissue by interacting with integral membrane proteins, also known as integrins. One application of this technology is an implantable prosthesis designed to treat blindness caused by outer retinal degenerative diseases. The device functions by bypassing damaged photoreceptors and providing electrical stimulation to the undamaged neurons of the retina. Markland has also pioneered the use of a silicone microelectrode array (MEA) which facilitates this electrical stimulation. A safe and effective protein adhesive is utilized for adhering the MEA to the retinal surface, thereby mitigating focal pressure effects.

In addition to his work on implants, Markland's patent for the method of expressing proteins with disulfide bridges addresses the challenge of increasing yields and activity of these proteins. His methods focus on optimizing the conditions under which Origami B cells are grown, promoting a redox environment that enhances the production of correctly-folded, active protein conformers, such as the chimeric variant of snake venom disintegrin.

Career Highlights

Throughout his career, Markland has been associated with notable institutions, including the University of Southern California. His experiences in these environments have enriched his expertise and facilitated his groundbreaking innovations. His 16 patents reflect a deep commitment to advancing biomedical technologies.

Collaborations

In his journey as an inventor, Markland has collaborated with esteemed colleagues, notably Radu O. Minea and Qing Zhou. These partnerships have played a crucial role in the development of his inventions and reflect a collaborative spirit that is essential in scientific research.

Conclusion

Francis S. Markland, Jr.'s contributions to biocompatible implants and protein expression represent a significant leap forward in medical technology. His innovative patents are poised to improve treatment options for patients suffering from various medical conditions. As he continues to advance the field of biotechnology, his work inspires future generations of inventors and researchers.