Elliott D Kieff

Title: Innovations and Contributions of Elliott D Kieff

Introduction

Elliott D Kieff is a notable inventor based in Brookline, MA (US). He has made significant contributions to the field of virology and gene therapy, holding a total of 7 patents. His work focuses on understanding and manipulating viral mechanisms to improve therapeutic outcomes.

Latest Patents

One of Kieff's latest patents involves assays for compounds that modulate rhadino virus LANA action in trans on a unit of rhadino virus DNA. This invention aims to mediate efficient episome persistence in primary effusion lymphoma (PEL) cells, which harbor Kaposi's sarcoma-associated herpesvirus (KSHV) episomes. The research highlights the co-localization of LANA and KSHV DNA in interphase nuclei and along mitotic chromosomes. Kieff's findings suggest that LANA is essential for the persistence of episomes containing specific KSHV DNA fragments. Additionally, he has developed a non-defective Epstein-Barr viral vector system that effectively inserts transgenes into the EBV major internal repeat region without adversely affecting EBV functions.

Career Highlights

Throughout his career, Kieff has worked with prestigious institutions, including The Brigham and Women's Hospital, Inc. His research has significantly advanced the understanding of viral behavior and its implications for gene therapy.

Collaborations

Kieff has collaborated with esteemed colleagues such as Mary E Ballestas and Kenneth M Kaye. Their joint efforts have contributed to the development of innovative solutions in the field of virology.

Conclusion

Elliott D Kieff's work exemplifies the intersection of innovation and medical research, showcasing his commitment to advancing therapeutic techniques through his patents and collaborations. His contributions continue to impact the field positively.