This inventor holds 2 USPTO granted patents, plus 1 CIPO patent and 1 EPO patent. Top assignees: Barbara Ann Karmanos Cancer Institute, Scitech Development, LLC. Active years: 2006-2014.
Company Filing History:
Years Active: 2006-2014
Title: Earle T Holsapple: Innovator in Drug Delivery and Diagnostic Analysis
Introduction
Earle T Holsapple is a notable inventor based in Grosse Pointe Farms, MI (US). He has made significant contributions to the fields of drug delivery and diagnostic analysis, holding a total of 2 patents. His work focuses on innovative formulations and methods that enhance therapeutic efficacy and diagnostic capabilities.
Latest Patents
Holsapple's latest patents include advancements in liposomal nanoparticles and other formulations of fenretinide for therapeutic use. These formulations utilize lipid nanoparticles, solid dispersions, and emulsions to treat neoplastic diseases by achieving higher and more prolonged concentrations of fenretinide in patients. The preparation of these lipid nanovesicles involves key steps such as mixing, sonication, and sterile filtration, ensuring scalability from laboratory to manufacturing levels. Importantly, these formulations are designed to be suitable for injection into human or animal patients without causing allergic or hypersensitivity responses, as they avoid chemical surfactants and animal sources of phospholipids.
Another significant patent involves a method and apparatus for investigating tissue through diagnostic analysis of ultrasound data. This method derives acoustic data from scattering pulsed spherical or cylindrical acoustic waves through tissue, allowing for the generation of a representation of the tissue from the digitized acoustic data.
Career Highlights
Throughout his career, Earle T Holsapple has worked with esteemed organizations such as the Barbara Ann Karmanos Cancer Institute and Scitech Development, LLC. His contributions in these roles have furthered the development of innovative therapeutic and diagnostic solutions.
Collaborations
Holsapple has collaborated with notable individuals in his field, including David H Chambers and Jeffrey Edward Mast. These collaborations have likely enriched his research and development efforts, leading to impactful innovations.
Conclusion
Earle T Holsapple's work exemplifies the intersection of innovation and healthcare, with his patents paving the way for advancements in drug delivery and diagnostic methods. His contributions continue to influence the fields of medicine and technology.