The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 29, 2014
Filed:
Mar. 29, 2007
Ralph E. Parchment, Hagerstown, MD (US);
Bhaskara R. Jasti, Stockton, CA (US);
Ramesh R. Boinpally, Broomfield, CO (US);
Stephen E. Rose, Flushing, MI (US);
Earle T. Holsapple, Grosse Pointe Farms, MI (US);
Ralph E. Parchment, Hagerstown, MD (US);
Bhaskara R. Jasti, Stockton, CA (US);
Ramesh R. Boinpally, Broomfield, CO (US);
Stephen E. Rose, Flushing, MI (US);
Earle T. Holsapple, Grosse Pointe Farms, MI (US);
Scitech Development, LLC, Grosse Pointe Farms, MI (US);
Abstract
Formulations of neutral retinoids, in particular fenretinide (HPR) in the form of lipid nanoparticles, solid dispersions and emulsions are disclosed. These compositions are used to treat diseases that are amenable to treatment by HPR, such as neoplastic diseases by achieving higher and more prolonged concentrations of HPR in the subject. The key steps for preparing lipid nanovesicles of HPR include mixing and sonication, sterile filtration, without or without lyophilization for long-term stable storage, and employ processes and materials that are scalable from the laboratory to the manufacturing level. The formulation are suitable for injection into human or animal patients without causing allergic or hypersensitivity responses by avoiding chemical surfactants and animal sources of phospholipids in their manufacture.