Barbara Ann Karmanos Cancer Institute

Scitech Development, LLC

Wayne State University

Jasti, Bhaskara R.

Earle T Holsapple

Peter John Littrup

David H Chambers

Jeffrey Edward Mast

Ralph E Parchment

Stephen G Azevedo

Frank Natterer

Bhaskara Rao Jasti

Frank Wuebbeling

Neb Duric

Ramesh R Boinpally

Stephen E Rose

Bhaskara R Jasti

Steven E Rose

Formulations of neutral retinoids, in particular fenretinide (HPR) in the form of lipid nanoparticles, solid dispersions and emulsions are disclosed. These compositions are used to treat diseases that are amenable to treatment by HPR, such as neoplastic diseases by achieving higher and more prolonged concentrations of HPR in the subject. The key steps for preparing lipid nanovesicles of HPR include mixing and sonication, sterile filtration, without or without lyophilization for long-term stable storage, and employ processes and materials that are scalable from the laboratory to the manufacturing level. The formulation are suitable for injection into human or animal patients without causing allergic or hypersensitivity responses by avoiding chemical surfactants and animal sources of phospholipids in their manufacture.

Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery

A method and apparatus are provided for investigating tissue in which acoustic data are derived from scattering a plurality of pulsed spherical or cylindrical acoustic waves from a plurality of transmission elements through the tissue to a plurality of receiving elements. The acoustic data, which include a mix of reflected and transmitted acoustic waves, are received and digitized, and a representation of a portion of the tissue is generated from the digitized acoustic data.

Diagnostic analysis of ultrasound data

Growing community of inventors

Grosse Pointe Farms, MI, United States of America

Earle T Holsapple