Douglas Stephen English

Title: Douglas Stephen English: Innovator in Antibacterial Compounds and Nanotechnology

Introduction

Douglas Stephen English is a notable inventor based in Derby, Kansas. He holds a total of 4 patents that contribute significantly to the fields of antibacterial compounds and nanotechnology. His innovative work focuses on developing methods to inhibit bacterial growth and create advanced materials for therapeutic applications.

Latest Patents

One of his latest patents involves compounds for inhibiting bacterial growth via phosphatidylglycerol binding. These antibacterial small molecule compounds, termed liptins, bind to phosphatidylglycerol in bacterial plasma membranes. The small molecule compounds are designed with a three-dimensional complementary binding pocket for phosphatidylglycerol, which disrupts membrane function in a bacteriostatic or bactericidal manner. This patent also discloses methods for inhibiting bacterial growth and treating both Gram-positive and Gram-negative bacterial infections using these compounds.

Another significant patent by Douglas English is for a method of forming mesoporous silica nanoparticles. This patent provides a method for synthesizing mesoporous silica nanoparticles and outlines their applications. The method includes fractionating a mesoporous silica nanoparticle suspension to produce size-fractionated nanoparticles. It further details the etching process of these nanoparticles to create a hollow, porous morphology that can receive therapeutic agents or imaging materials. The controlled release of the target material is achieved by decreasing the physiological pH of the nanoparticle's surface.

Career Highlights

Douglas English has worked with esteemed institutions such as the University System of Maryland and Wichita State University. His contributions to research and development in these organizations have been instrumental in advancing scientific knowledge and practical applications in his fields of expertise.

Collaborations

Some of his notable coworkers include Gregory F. Payne and Philip R. DeShong. Their collaborative efforts have likely enhanced the innovation and effectiveness of the projects they have worked on together.

Conclusion

Douglas Stephen English is a distinguished inventor whose work in antibacterial compounds and nanotechnology has made a significant impact. His patents reflect a commitment to advancing science and improving health outcomes through innovative solutions.