The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 01, 2016
Filed:
Mar. 06, 2009
Philip R. Deshong, Silver Spring, MD (US);
Michael R. Zachariah, Potomac, MD (US);
Peter Demuth, Towson, MD (US);
Anand Prakash, Wilmington, MA (US);
Charles Luckett, Greenbelt, MD (US);
Douglas Stephen English, Wichita, KS (US);
Philip R. DeShong, Silver Spring, MD (US);
Michael R. Zachariah, Potomac, MD (US);
Peter DeMuth, Towson, MD (US);
Anand Prakash, Wilmington, MA (US);
Charles Luckett, Greenbelt, MD (US);
Douglas Stephen English, Wichita, KS (US);
UNIVERSITY OF MARYLAND, College Park, MD (US);
Abstract
A method for synthesizing a mesoporous silica nanoparticle, a mesoporous silica nanoparticle, and applications thereof are provided. The method includes fractionating a mesoporous silica nanoparticle suspension to produce size-fractionated mesoporous silica nanoparticle. The method further includes etching the size-fractionated mesoporous silica nanoparticle to produce synthesized mesoporous silica nanoparticle having a hollow, porous morphology configured to receive one of a therapeutic agent and an imaging material. The etching includes differential etching of silica from areas of low polymeric density within the mesoporous silica nanoparticle and re-depositing of the silica in areas of higher polymeric density existing near the surface of the mesoporous silica nanoparticle. A target material is loaded into the synthesized mesoporous silica nanoparticle and a controlled released of the target material is provided by decreasing the physiological pH of the surface of the mesoporous silica nanoparticle.