Douglas H Keith

Title: **Douglas H. Keith: Innovator in Molecular Detection and Automation**

Introduction

Douglas H. Keith is a prominent inventor based in Oakland, California, recognized for his contributions to the fields of molecular biology and laboratory automation. With a total of four patents to his name, his innovative work has significantly advanced the methodologies used in nucleic acid detection and automated laboratory processes.

Latest Patents

One of Keith's latest patents focuses on a method for nucleic acid detection that employs a multi-step process. This innovative approach involves labeling sample nucleic acid sequences and duplexing these with a probe that contains a coupling element. The technique allows for the immobilization of the duplexed probe and target sequence while separating specifically immobilized nucleic acids from the residual free and non-specifically immobilized nucleic acids. The process culminates in the detection of the nucleic acid sequence of interest, which may be characterized by tools such as electrophoresis. This method is lauded for its sensitivity and rapidity, providing a precise means for detecting nucleic acid sequences across various contexts.

Another notable patent is centered around the development of an advanced liquid-handling instrument. This system features a worksurface designed for modular stations that can support various containers and pipette apparatuses. It incorporates a robotic translation system for pipette tip movement and a user-friendly control system for programming and editing tasks. The invention includes capabilities for calibration, liquid aspiration with minimal contamination, and a unique duck-billed closure that minimizes evaporation and cross-contamination.

Career Highlights

Douglas H. Keith has built an extensive career, serving in influential roles within reputed organizations such as Applied Biosystems, LLC and PerkinElmer Corporation, Applied Biosystems Division. His experience in these industry-leading companies has contributed to the robustness of his inventions and a deep understanding of molecular detection techniques and automation.

Collaborations

Throughout his career, Keith has collaborated with talented professionals including Lincoln J. McBride and Norman M. Whiteley. These collaborations have not only enriched his work but have also fostered a shared environment of innovation and expertise within the field.

Conclusion

In summary, Douglas H. Keith stands out as an inventor whose work is transforming the landscape of molecular biology and laboratory technologies. His patented innovations, particularly in nucleic acid detection and laboratory automation, underscore his commitment to improving scientific methodologies. Through his collaborations and experience with major companies, Keith continues to inspire and shape the future of research innovations.