Company Filing History:
Years Active: 2008
Title: The Innovative Contributions of Douglas G Brooks
Introduction
Douglas G Brooks is a notable inventor based in San Marcos, CA (US). He has made significant contributions to the field of synthetic compounds, particularly in the preparation of oligonucleotides. His innovative work has led to the development of a unique system that enhances the efficiency of generating active compounds.
Latest Patents
Douglas G Brooks holds a patent for a "System of components for preparing oligonucleotides." This invention involves interactive, preferably computer-based iterative processes for generating synthetic compounds with desired physical, chemical, and/or bioactive properties. The process includes providing or selecting a target nucleic acid sequence and generating a library of candidate nucleobase sequences in silico according to defined criteria. A 'virtual' oligonucleotide chemistry is chosen, leading to the generation of a library of virtual oligonucleotide compounds. These compounds are then reviewed, and those predicted to have particular properties are selected for robotic synthesis and assay for desired activities. This innovative approach not only generates active compounds but also identifies preferred sequences and regions of the target nucleic acid that are amenable to modulation.
Career Highlights
Douglas G Brooks is associated with Isis Pharmaceuticals, Inc., where he applies his expertise in the field of oligonucleotide chemistry. His work has been instrumental in advancing the capabilities of synthetic compound generation, making significant strides in the pharmaceutical industry.
Collaborations
Throughout his career, Douglas has collaborated with notable colleagues, including Lex M Cowsert and Brenda F Baker. These collaborations have further enriched his research and development efforts in the field.
Conclusion
Douglas G Brooks is a distinguished inventor whose work in oligonucleotide preparation has paved the way for advancements in synthetic compounds. His innovative patent and contributions to Isis Pharmaceuticals, Inc. highlight his commitment to enhancing the field of biotechnology.