The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 22, 2008
Filed:
Apr. 28, 1998
Lex M. Cowsert, Carlsbad, CA (US);
Brenda F. Baker, Carlsbad, CA (US);
John Mcneil, La Jolla, CA (US);
Susan M. Freier, San Diego, CA (US);
Henri M. Sasmor, Oceanside, CA (US);
Douglas G. Brooks, San Marcos, CA (US);
Cara Ohashi, San Francisco, CA (US);
Jacqueline R. Wyatt, Encinitas, CA (US);
Alexander H. Borchers, Encinitas, CA (US);
Timothy A. Vickers, Oceanside, CA (US);
Lex M. Cowsert, Carlsbad, CA (US);
Brenda F. Baker, Carlsbad, CA (US);
John McNeil, La Jolla, CA (US);
Susan M. Freier, San Diego, CA (US);
Henri M. Sasmor, Oceanside, CA (US);
Douglas G. Brooks, San Marcos, CA (US);
Cara Ohashi, San Francisco, CA (US);
Jacqueline R. Wyatt, Encinitas, CA (US);
Alexander H. Borchers, Encinitas, CA (US);
Timothy A. Vickers, Oceanside, CA (US);
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A 'virtual' oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the selected nucleobase sequences is generated. These virtual compounds are reviewed and compounds predicted to have particular properties are selected. The selected compounds are robotically synthesized and are preferably robotically assayed for a desired physical, chemical or biological activity. Active compounds are thus generated and, at the same time, preferred sequences and regions of the target nucleic acid that are amenable to oligonucleotide or sequence-based modulation are identified.