Alexander H Borchers

Title: The Innovations of Alexander H Borchers

Introduction

Alexander H Borchers is a notable inventor based in Encinitas, CA (US). He has made significant contributions to the field of biotechnology, particularly in the development of oligonucleotide synthesis and modulation of protein expression. With a total of 4 patents, his work has advanced the understanding and application of synthetic compounds in various biological contexts.

Latest Patents

Borchers' latest patents include a system of components for preparing oligonucleotides. This innovative approach involves interactive, computer-based iterative processes for generating synthetic compounds with desired physical, chemical, and bioactive properties. During these iterations, a target nucleic acid sequence is selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A 'virtual' oligonucleotide chemistry is chosen, leading to the generation of a library of virtual oligonucleotide compounds. These compounds are then reviewed, and those predicted to have particular properties are selected for robotic synthesis and assay. This process not only generates active compounds but also identifies preferred sequences and regions of the target nucleic acid for modulation.

Another significant patent focuses on antisense modulation of hematopoietic cell protein tyrosine kinase expression. This patent provides antisense compounds, compositions, and methods for modulating the expression of this specific protein. The compositions include antisense oligonucleotides targeted to nucleic acids encoding hematopoietic cell protein tyrosine kinase. The methods outlined in this patent are aimed at using these compounds for the modulation of protein expression and for the treatment of diseases associated with this expression.

Career Highlights

Borchers is currently associated with Isis Pharmaceuticals, Inc., where he continues to innovate in the field of biotechnology. His work has been instrumental in advancing therapeutic strategies that leverage oligonucleotide technology.

Collaborations

Throughout his career, Borchers has collaborated with notable colleagues, including Lex M Cowsert and Brenda F Baker. These collaborations have contributed to the successful development of his patented technologies.

Conclusion

Alexander H Borchers is a prominent figure in the field of biotechnology, with a focus on oligonucleotide synthesis and modulation. His innovative patents and collaborations have significantly impacted the development of therapeutic strategies in this area.