Company Filing History:
Years Active: 2005-2007
Title: Douglas B. Starr: Innovator in Molecular Switch Systems
Introduction
Douglas B. Starr is a notable inventor based in Mountain View, CA (US). He has made significant contributions to the field of molecular biology, particularly in the development of innovative gene expression systems. With a total of 2 patents, his work has the potential to impact various applications in biotechnology and medicine.
Latest Patents
Starr's latest patents include a DNA binding compound-mediated molecular switch system. This invention provides methods and compositions for regulatable gene expression. The system comprises a nucleic acid construct with a DNA response sequence for a transcriptional regulatory protein linked to a promoter, a compound binding sequence near the DNA response sequence, a transgene under the control of the promoter, and a DNA binding compound. Additionally, the molecular switch system may include a nucleic acid sequence encoding a transcriptional regulatory protein linked to a second promoter. The invention also outlines a method for screening compounds that can function within the molecular switch system to regulate gene expression.
Another significant patent focuses on promoters for regulated gene expression. This invention provides nucleic acid sequences, vectors, and host cells that include regulatory regions associated with various promoters. These include a cyclin D1 promoter, a CD40L promoter, three HBV promoters (core, pre-S1, and HBV-X), a vancomycin-resistant enterococci (VRE) promoter, an androgen receptor promoter, a Her2 promoter, and a β-lactamase promoter. The invention further details methods for regulating gene expression using these regulatory regions.
Career Highlights
Douglas B. Starr is currently associated with Genelabs Technologies, Inc., where he continues to advance his research in molecular biology. His work has garnered attention for its innovative approach to gene regulation and expression.
Collaborations
Starr has collaborated with notable colleagues, including Thomas W. Bruice and Megan E. Laurance. These partnerships have contributed to the development of his groundbreaking inventions.
Conclusion
Douglas B. Starr is a prominent figure in the field of molecular biology, with a focus on innovative gene expression systems. His patents reflect a commitment to advancing scientific knowledge and technology in this vital area.