Genelabs Technologies, Inc.

Douglas B Starr

Thomas W Bruice

Albert W Tam

Megan E Laurance

Kirk E Fry

Jungsuh P Kim

Cynthia A Edwards

Mark Douglas Velligan

Emil F Michelotti

Yan Kwok

Moon Young Lim

Derek R Latour

Rita L Thomas

Ana Kongpachith

Liana T Sheppard

Moon Young Kim

The present invention provides molecular switch system methods and compositions for use in regulatable gene expression. The system includes a nucleic acid construct which has a DNA response sequence for a transcriptional regulatory protein operably linked to a promoter, a compound binding sequence in the vicinity of the DNA response sequence, a transgene under the control of the promoter; and a DNA binding compound. In some cases, the molecular switch system further includes a nucleic acid sequence encoding a transcriptional regulatory protein operably linked to a second promoter. The invention further provides a method for screening compounds for the ability to function in the molecular switch system and thereby regulate gene expression.

DNA binding compound-mediated molecular switch system

This invention provides nucleic acid sequences, vectors and host cells comprising regulatory regions associated with various promoters including a cyclin D1 promoter, a CD40L promoter, three HBV promoters (core, pre-S1 and HBV-X), a vancomycin-resistant enterococci (VRE) promoter, an androgen receptor promoter, a Her2 promoter, and &#x3b2;-lactamase promoter. The invention further provides methods of regulating gene expression comprising the regulatory regions of such promoters.

Promoters for regulated gene expression

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Mountain View, CA, United States of America

Douglas B Starr