The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 13, 2007
Filed:
Mar. 03, 2000
Moon Young Lim, Redwood City, CA (US);
Cynthia A. Edwards, Morgan Hill, CA (US);
Kirk E. Fry, Palo Alto, CA (US);
Thomas W. Bruice, Carlsbad, CA (US);
Douglas B. Starr, Mountain View, CA (US);
Megan E. Laurance, San Francisco, CA (US);
Yan Kwok, Sunnyvale, CA (US);
Albert W. Tam, San Francisco, CA (US);
Moon Young Lim, Redwood City, CA (US);
Cynthia A. Edwards, Morgan Hill, CA (US);
Kirk E. Fry, Palo Alto, CA (US);
Thomas W. Bruice, Carlsbad, CA (US);
Douglas B. Starr, Mountain View, CA (US);
Megan E. Laurance, San Francisco, CA (US);
Yan Kwok, Sunnyvale, CA (US);
Albert W. Tam, San Francisco, CA (US);
Genelabs Technologies, Inc., Redwood City, CA (US);
Abstract
The present invention provides molecular switch system methods and compositions for use in regulatable gene expression. The system includes a nucleic acid construct which has a DNA response sequence for a transcriptional regulatory protein operably linked to a promoter, a compound binding sequence in the vicinity of the DNA response sequence, a transgene under the control of the promoter; and a DNA binding compound. In some cases, the molecular switch system further includes a nucleic acid sequence encoding a transcriptional regulatory protein operably linked to a second promoter. The invention further provides a method for screening compounds for the ability to function in the molecular switch system and thereby regulate gene expression.