Company Filing History:
Years Active: 2003-2007
Title: Yan Kwok: Innovator in Molecular Switch Systems and Antineoplastic Agents
Introduction
Yan Kwok is a notable inventor based in Sunnyvale, CA (US). He has made significant contributions to the field of molecular biology and medicinal chemistry. With a total of 2 patents, his work focuses on innovative solutions for gene expression regulation and cancer treatment.
Latest Patents
One of his latest patents is titled "DNA binding compound-mediated molecular switch system." This invention provides methods and compositions for regulatable gene expression. The system includes a nucleic acid construct with a DNA response sequence for a transcriptional regulatory protein linked to a promoter, a compound binding sequence near the DNA response sequence, a transgene under the control of the promoter, and a DNA binding compound. Additionally, the molecular switch system may include a nucleic acid sequence encoding a transcriptional regulatory protein linked to a second promoter. The invention also offers a method for screening compounds that can function within the molecular switch system to regulate gene expression.
Another significant patent is "Synthesis of quinobenzoxazine analogues with topoisomerase II and quadruplex interactions for use as antineoplastic agents." This invention discloses a novel quinobenzoxazine self-assembly complex on DNA and the topoisomerase II-DNA complex. The model is utilized to design a new series of quinobenzoxazines and related compounds that may exhibit anticancer or antibiotic activity. The anticancer activity is believed to operate through the stabilization of the topoisomerase II-DNA complex and/or interaction with G-quadruplexes. The antibiotic activity is derived from the compounds' ability to inhibit gyrase, the bacterial type II topoisomerase.
Career Highlights
Yan Kwok has worked with esteemed organizations such as the University of Texas System and Genelabs Technologies, Inc. His experience in these institutions has contributed to his innovative research and development in the field.
Collaborations
Throughout his career, Yan has collaborated with notable individuals, including Laurence H Hurley and Qingping Zeng. These partnerships have further enhanced his research capabilities and contributions to the scientific community.
Conclusion
Yan Kwok is a distinguished inventor whose work in molecular switch systems and antineoplastic agents has the potential to impact gene expression regulation and cancer treatment significantly. His innovative patents and collaborations reflect his commitment to
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