Diwahar L Narasimhan

Title: The Innovative Contributions of Diwahar L. Narasimhan

Introduction

Diwahar L. Narasimhan, based in Ann Arbor, MI, is a distinguished inventor recognized for his significant contributions to the field of therapeutic innovations. With a portfolio of five patents, his work primarily focuses on addressing cocaine-induced conditions through advanced biochemical methods.

Latest Patents

One of his notable patents is centered on the "Thermostabilization of proteins." This innovation provides compositions that include cocaine esterase (CocE) combined with compounds designed to enhance the thermostability of CocE. Additionally, it outlines methods to stabilize this enzyme and presents techniques for treating mammals suffering from cocaine-related conditions. Narasimhan's patent also includes an isolated nucleic acid coding for a CocE polypeptide with specific substitutions aimed at improving therapeutic efficacy.

Another significant patent involves "Anti-cocaine compositions and treatment," which describes advanced anti-cocaine therapeutics. This invention focuses on the development of highly efficient and thermostable CocE mutants capable of mitigating the harmful effects of cocaine. The methods elaborated in this patent detail the treatment of cocaine-induced conditions through the administration of these mutant polypeptides and include processes for high-throughput screening of candidate esterase polypeptides.

Career Highlights

Throughout his career, Diwahar has worked at prestigious institutions, including the University of Michigan and Columbia University in the City of New York. His research has significantly impacted the scientific community, especially in developing therapies for addiction treatment.

Collaborations

Narasmihan has collaborated with esteemed colleagues, including James H. Woods and Roger K. Sunahara, enhancing his research endeavors and broadening the scope of his innovative projects. Together, they have contributed to advancing therapeutic approaches aimed at combating cocaine addiction.

Conclusion

Diwahar L. Narasimhan’s inventive work presents promising advancements in the treatment of cocaine-induced conditions. His ongoing research and patent contributions play a crucial role in developing effective therapeutic solutions, showcasing his dedication to innovation in the biomedical field.