The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2016
Filed:
Jan. 28, 2014
Donald W. Landry, New York, NY (US);
James H. Woods, Ann Arbor, MI (US);
Roger K. Sunahara, Ann Arbor, MI (US);
Diwahar L. Narasimhan, Ann Arbor, MI (US);
Joanne Macdonald, New York, NY (US);
Milan N. Stojanovic, Fort Lee, NJ (US);
John J. Tesmer, Ann Arbor, MI (US);
Remy L. Brim, Farmington Hills, MI (US);
Donald W. Landry, New York, NY (US);
James H. Woods, Ann Arbor, MI (US);
Roger K. Sunahara, Ann Arbor, MI (US);
Diwahar L. Narasimhan, Ann Arbor, MI (US);
Joanne MacDonald, New York, NY (US);
Milan N. Stojanovic, Fort Lee, NJ (US);
John J. Tesmer, Ann Arbor, MI (US);
Remy L. Brim, Farmington Hills, MI (US);
The Trustee of Columbia University in the City of New York, New York, NY (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
Abstract
Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.