The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2015
Filed:
Nov. 14, 2012
The Trustees of Columbia University IN the City of New York, New York, NY (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
The University of Kentucky Research Foundation, Lexington, KY (US);
Donald Landry, New York, NY (US);
Chang-Guo Zhan, Lexington, KY (US);
James H. Woods, Ann Arbor, MI (US);
Roger Sunahara, Ann Arbor, MI (US);
Diwahar L. Narasimhan, Ann Arbor, MI (US);
Joanne MacDonald, New York, NY (US);
Victor Yang, Ann Arbor, MI (US);
Mei-Chuan Holden Ko, Ann Arbor, MI (US);
Shi-Xian Deng, White Plains, NY (US);
John J. Tesmer, Ann Arbor, MI (US);
Tien-Yi Lee, Ann Arbor, MI (US);
Young Min Kwon, Ann Arbor, MI (US);
Daquan Gao, Louisville, KY (US);
The Trustees of Columbia University in the City of New York, New York, NY (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
University of Kentucky Research Foundation, Lexington, KY (US);
Abstract
Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.