Company Filing History:
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Years Active: 2005-2009
Title: Ditlev Egeskov Brodersen: Innovator in Ribosomal Research
Introduction
Ditlev Egeskov Brodersen is a prominent inventor based in Cambridge, GB. He has made significant contributions to the field of ribosomal research, particularly in the development of antibiotics. With a total of 3 patents, his work has the potential to impact medical science and antibiotic development.
Latest Patents
Brodersen's latest patents include groundbreaking inventions related to the crystal structure of the 30S ribosome. One of his notable inventions provides an X-ray crystal structure of the 30S ribosome, obtained from the 30S subunit, which has a tetragonal space group P422. The unit cell dimensions are a=401.4±4.0 Å, b=401.4±4.0 Å, and c=175.9±5.0 Å. An advantageous feature of this structure is its ability to diffract beyond 3 Å resolution. This invention also includes a crystal of the 30S ribosome with three-dimensional atomic coordinates, which can be utilized for the rational design and modeling of inhibitors for the 30S ribosome, potentially leading to new antibiotics.
Another significant patent focuses on the crystal structure of antibiotics bound to the 30S ribosome. This invention provides high-resolution X-ray crystal structures of the 30S ribosome, which are bound to various antibiotics, including paromomycin, streptomycin, spectinomycin, tetracycline, pactamycin, and hygromycin B. The structure also diffracts at about 3 Å resolution, and the data can be used for the rational design and modeling of inhibitors for the 30S ribosome.
Career Highlights
Throughout his career, Brodersen has worked with esteemed organizations such as the Medical Research Council and the University of Utah Research Foundation. His research has significantly advanced the understanding of ribosomal structures and their interactions with antibiotics.
Collaborations
Brodersen has collaborated with notable scientists, including Venkatraman Ramakrishnan and Andrew Philip Carter. These collaborations have further enriched his research and contributed to the scientific community's understanding of ribosomal function.
Conclusion
Ditlev Egeskov Brodersen's innovative work in ribosomal research and antibiotic development showcases his dedication to