The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2006
Filed:
Sep. 17, 2001
Venkatraman Ramakrishnan, Cambridge, GB;
Ditlev Egeskov Brodersen, Cambridge, GB;
Andrew Philip Carter, Cambridge, GB;
Venkatraman Ramakrishnan, Cambridge, GB;
Ditlev Egeskov Brodersen, Cambridge, GB;
Andrew Philip Carter, Cambridge, GB;
Medical Research Council, London, GB;
Abstract
The invention provides high resolution X-ray crystal structures of the 30S ribosome, obtained from30S subunit, having a tetragonal space group P422 to which are bound an antibiotic selected from the group paromomycin, streptomycin, spectinomycin, tetracycline, pactamycin and hygromycin B. An advantageous feature of the structure is that it diffracts at about 3 Å resolution. The invention also provides a crystal of 30S having the three dimensional atomic coordinates of the 30S ribosome, the coordinates being provided in any one of tables 1 to 4. The data may be used for the rational design and modelling of inhibitors for the 30S ribosome, which have potential use as antibiotics.